Refit Tablet, Capsule
Metoprolol is a selective beta 1-blocker. Metoprolol reduces or inhibits the atonic effect of ketolmimens on the heart (which is manifested during physical and emotional stress). This means that the heart rate, cardiac output, cardiac contractility and normal increase in blood pressure, produced by a sharp increase in ketolmines, decrease metoprolol. Metropolis interferes less with insulin secretion and carbohydrate metabolism than with non-selective beta-blockers. Metropolis rarely interferes with the cardiovascular response to hypoglycemia than non-selective beta-blockers.
Use
Prevention of high blood pressure, angina pectoris, myocardial infarction, irregular heartbeat, heart failure, hyperthyroidism, migraine.
Refit Tablet, Capsule in bangla
Trade name Refit
Generic metoprolol tartrate
Type Tablet, Capsule
Measurements 100mg, 2mg
Medical class Beta-adrenoceptor blocking drugs, Beta-blockers
Manufacturer Mass Pharma (private) Limited, Antik Biotech
Available countries Pakistan, India
Last edited June 23, 2021 at 4:31 pm
Table of contents
Refit
Work
Rules of eating
Side effects
Caution
Interaction
Use during pregnancy
Acute overdose
Interactions with other drugs
Contrast
Save
Rules of eating
Refit eating rules
Hypertension: The initial dose is 100 mg. Daily, Maintenance Dosage 100 - 200 mg. 1-2 times a day in divided doses.
Angina pectoris: 50 - 100 mg. 2-3 times a day.
Myocardial infarction: Initial treatment: 50 mg. (For patients who are able to tolerate full dose intravenously) or 25 - 50 mg. (For patients who are unable to tolerate full intravenous doses) 15 minutes after the last intravenous medication or every 6 hours as the condition improves. This level will last for 48 hours and will change according to the following rules.
Further treatment: 100 mg. Serve orally at least twice a day for 3 months and if possible for 1 - 3 years.
Irregular heartbeat: usually 50 mg. 2-3 times a day, 300 mg daily if required. Have to share
Heart failure: 12.5 - 25 mg. Tablets once daily.
After 2 weeks the dose is increased to 200 mg. Once a day.
Hyperthyroidism: 50 mg. 4 times a day.
Migraine prevention: 100 - 200 mg. In divided doses per day. Or use according to the doctor's advice.
Side effects
Increased severity of bradycardia, heart failure, hypertension, conduction problems, bronchospasm, peripheral vasoconstriction, digestive problems, fatigue, sleep problems, rarely rashes and dry eyes, sexual dysfunction and psoriasis.
Caution
Oral consumption may be reduced in people with liver problems. Sudden metoprolol intake should not be discontinued in angina and its initial levels may be reduced in renal complications. It is contraindicated in those who are hypersensitive to metoprolol and other beta blockers.
Interaction
Plasma levels of metrophores can be raised by co-administration of metabolic compounds by CYP2D6 such as antiarrhythmics, antihistamines, anti-H2 receptors, antidepressants, antipsychotics and Cox-2 inhibitors. Plasma concoction reduces rifampicin of metoprolol.
Use during pregnancy
Pregnancy category ‘C’. Breastfeeding mothers should be careful when taking metoprolol.
Use in children: Its effectiveness and safety in children has not been established.
Contrast
It is contraindicated in those who are hypersensitive to metoprolol or other beta blockers. It also refers to the following cases:
Hypertension and angina: sinus bradycardia, if the heart block is more than the first level, cardiogenic shock, over cardiac failure.
Myocardial infarction: abnormal bradycardia, first degree heart block, systolic hypotension (<100 mm Hg) or acute heart failure.
Extra caution
Renal Impairment: No dose adjustment is required.
Hepatic impairment: Reduce the dose.
Acute overdose
Poisoning due to an overdose of metoprolol may lead to severe hypotension, sinus bradycardia, atrioventricular block, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, impairment of consciousness, coma, nausea, vomiting, cyanosis, hypoglycaemia and, occasionally, hyperkalaemia. The first manifestations usually appear 20 minutes to 2 hours after drug ingestion. Treatment: Treatment should include close monitoring of cardiovascular, respiratory and renal function, and blood glucose and electrolytes. Further absorption may be prevented by induction of vomiting, gastric lavage or administration of activated-charcoal if ingestion is recent. Cardiovascular complications should be treated symptomatically, which may require the use of sympathomimetic agents (e.g. noradrenaline, metaramionl), atropine or inotropic agents (e.g. dopamine, dobutamine). Temporary packing may be required for AV block. Glucagon can reverse the effects of excessive B-blockade, given in a dose of 1-10 mg intravenously. Intravenous B2-stimulants e.g. terbutaline may be required to relieve bronchospasm. Meto prolol cannot be effectively removed by haemodialysis.
Interactions with other drugs
People who take metoprolol and catecholamine depleters together should keep an eye out for low blood pressure or bradycardia. This can lead to headaches, low blood pressure or positional low blood pressure.
Save
Store in a cool, dry place protected from light. Keep out of reach of children.
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